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Discovery of Sexual Dimorphism in the Serum Metabolome of Parkinson’s Disease Patients Harboring Rare Genetic Variants with Uncertain Pathogenicity

2025-11-21

Abstract excerpt

Recent findings show that sex and genetic background impact serum metabolic profiles in idiopathic Parkinson’s disease (iPD) and carriers of pathogenic mutations (gPD). However, the metabolic consequences in patients harboring rare variants of uncertain pathogenic significance remain poorly understood. Here, we combined 1 H-Nuclear Magnetic Resonance (NMR) metabolomics with high-performance liquid chromatography...

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Literature Corpus work
969c1a54-5eeb-59d2-8284-f6de423e1c60
DOI
10.1101/2025.11.20.25340670
Open publication

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Discovery of Sexual Dimorphism in the Serum Metabolome of Parkinson’s Disease Patients Harboring Rare Genetic Variants with Uncertain PathogenicityDOI 10.1101/2025.11.20.25340670
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