Article

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

2024-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-associated neuroinflammation is the NF-κB and NLRP3 signaling axis. However, current treatments targeting NF-κB or NLRP3 may have adverse/systemic effects, and mos...

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Literature Corpus work: 6c68368c-de58-50a9-ba39-aec6749f3a82
DOI: 10.1101/2024.02.03.578493

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