Article

Suppressed macrophage response to quorum-sensing-active <i>Streptococcus pyogenes</i> occurs at the level of the nucleus

2025-02-08

Abstract excerpt

Streptococcus pyogenes , or Group A Streptococus (GAS), a significant human pathogen, employs quorum sensing (QS) systems to coordinate its behavior and genetic regulation in order to enhance survival. Our previous research established that one such QS system, the Rgg2/3 system, can suppress macrophage NFκB activity and production of pro-inflammatory cytokines. Yet, the scope of suppression and the mechanism by wh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16de04f9-45c7-57b0-81c5-5aecf768a391
DOI: 10.1101/2025.02.07.637189

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Suppressed macrophage response to quorum-sensing-active <i>Streptococcus pyogenes</i> occurs at the level of the nucleusDOI 10.1101/2025.02.07.637189Read

A <i>Streptococcus</i> quorum sensing system enables suppression of innate immunitySemantic proximity Read

A Streptococcus Quorum Sensing System Enables Suppression of Innate ImmunitySemantic proximity Read

A teichoic acid-like wall modification associated with immune suppression is socially regulated in <i>Streptococcus pyogenes</i>Semantic proximity Read

Colonization of the murine oropharynx by <i>Streptococcus pyogenes</i> is governed by the Rgg2/3 quorum sensing systemSemantic proximity Read

The Proteomic and Transcriptomic Landscapes Altered by Rgg2/3 Activity in Streptococcus pyogenesSemantic proximity Read

The proteomic and transcriptomic landscapes altered by Rgg2/3 activity in <i>Streptococcus pyogenes</i>Semantic proximity Read

Streptococcus pyogenes (“Group A Streptococcus”), a Highly Adapted Human Pathogen—Potential Implications of Its Virulence Regulation for Epidemiology and Disease ManagementSemantic proximity Read

Insights into <i>Streptococcus Pyogenes</i> Pathogenesis from Transcriptome StudiesSemantic proximity Read

Recent advances in understanding the molecular basis of group B<i>Streptococcus</i>virulenceSemantic proximity Read

Genome-wide protective response used by group A <i>Streptococcus</i> to evade destruction by human polymorphonuclear leukocytesSemantic proximity Read

Identification of Group A Streptococcus Genes Directly Regulated by CsrRS and Novel Intermediate RegulatorsSemantic proximity Read

Rgg2/Rgg3 quorum sensing is a determinant of <i>Streptococcus pyogenes</i> -host interactions in a murine intact skin infection modelSemantic proximity Read