Article
The PERK inhibitor GSK2606414 evokes developmental defects in zebrafish consistent with Wolcott-Rallison syndrome phenotypes.
Pharmacological reports : PR - 1 Apr 2026
Almeida Liliana M, Lima Leonor Pereira, Oliveira Nuno A S, Silva Rui F O, Sousa Bruno, Bessa José, Pinho Brígida R, Oliveira Jorge M A
Abstract excerpt
BACKGROUND: Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an endoplasmic reticulum stress kinase whose loss of function disturbs human development, leading to skeletal dysplasia and permanent neonatal diabetes, as in the Wolcott-Rallison Syndrome (WRS). The lack of effective, less invasive therapies for developmental diseases highlights the need for animal models that replicate complex...
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