Article

SHP2 binds directly to SOS1 to enable RAS activation

2026-06-13

Abstract excerpt

The protein-tyrosine phosphatase SHP2 ( PTPN11 ) regulates growth factor- and cytokine-induced RAS/ERK MAP kinase (MAPK) pathway activation, and aberrant SHP2 function causes developmental disorders and cancer 1–5 . It is widely believed that the catalytic activity of SHP2 is essential for pathway activation 1,4,6–8 . This view has shaped our interpretation of how germline PTPN11 mutations cause Noonan Syndrom...

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Literature Corpus work: ac8a2441-1b38-5a32-b82f-c1e8b9db79d4
DOI: 10.64898/2026.06.12.731952

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