Article

Polo-like Kinase-1, Aurora Kinase A and Wee1 Kinase Are Novel Therapeutic Targets in Chronic Myeloid Leukemia

2021-08-31

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>In chronic myeloid leukemia (CML), Aurora kinase A and Polo like kinase 1 (Plk1), two serine-threonine kinases involved in the maintenance of a functional G2/M checkpoint, may cooperate with the constitutive tyrosine-kinase (TK) activity of the BCR-ABL1 fusion protein increasing DNA damage, promoting the occurrence of additional genomic alterations ultimately driv...

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Literature Corpus work: 6c3d5925-4839-51eb-bc9e-a426d53c27c3
DOI: 10.21203/rs.3.rs-761130/v1

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