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Article

Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors

3 Nov 2020

Abstract excerpt

Dysfunctional DNA repair with subsequent genome instability and high mutational burden represents a major hallmark of cancer. In established malignant tumors, increased DNA repair capacity mediates resistance to DNA-damaging therapeutics, including cytotoxic drugs, radiotherapy, and selected small molecules including inhibitors of poly (ADP-ribose) polymerase (PARP), Ataxia Telangiectasia Mutated (ATM), ataxia...

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PMID: 33224881
DOI: 10.3389/fonc.2020.581217

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