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The multi-kinase inhibitor CG-806 exerts anti-cancer activity against acute myeloid leukemia by co-targeting FLT3, BTK, and Aurora kinases

2023-02-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Despite the development of several FLT3 inhibitors that have improved outcomes in patients with FLT3-mutant acute myeloid leukemias (AML), drug resistance is frequently observed, which may be associated with the activation of additional pro-survival pathways such as those regulated by BTK, aurora kinases, and potentially others in addition to acquired tyrosine k...

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Literature Corpus work
182c4691-a594-522c-83b4-2a103cb72e1b
DOI
10.21203/rs.3.rs-2570204/v1
Open publication

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