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Article

Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells

7 May 2017

Abstract excerpt

Quiescent and proliferating leukemia cells accumulate highly lethal DNA double-strand breaks that are repaired by 2 major mechanisms: BRCA-dependent homologous recombination and DNA-dependent protein kinase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas DNA repair pathways mediated by poly(ADP)ribose polymerase 1 (PARP1) serve as backups. Here we have designed a personalized medicine approach...

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PMID: 28481221
DOI: 10.1172/jci90825

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