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GDF15 and its receptors as pathways mediating smoking related weight change

16 Jun 2025

Abstract excerpt

Background Smokers have lower body weight than non-smokers, while smoking cessation results in weight gain. Understanding the mechanisms involved can help identify potential therapeutic targets to enhance smoking cessation. Methods We measured plasma levels of growth/differentiation factor 15 (GDF15), a stress-responsive protein, and its two receptors (proto-oncogene tyrosine-protein kinase receptor Ret [RET],...

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PMID: 40527012
DOI: 10.1016/j.ebiom.2025.105806

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