Article

Disentangling a Complex Response in Cell Reprogramming and Probing the Waddington Landscape by Automatic Construction of Petri Nets

2019-04-04

Abstract excerpt

We analyzed the developmental switch to sporulation of a multinucleate Physarum polycephalum plasmodial cell, a complex response to phytochrome photoreceptor activation. Automatic construction of Petri nets from trajectories of differential gene expression in single cells revealed alternative, genotype-dependent interconnected developmental routes and identified metastable states, commitment points, and subsequen...

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Literature Corpus work: 6ba12f5d-b21e-58fd-8d0a-7b20c6aecb9c
DOI: 10.1101/599191

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