Article

Deficiency of histone H3K36 methyltransferase SETD2 inhibits proliferation and migration of hepatocellular carcinoma through ERK pathway

2023-11-09

Abstract excerpt

<h4>Background: </h4> Hepatocellular carcinoma (HCC) is one of the leading cause of cancer-related death worldwide. SETD2, as the only known methyltransferase for catalyzing trimethylation of histone H3 lysine 36 (H3K36), has been reported to be associated with several cancers. However, the function of SETD2 in HCC is ambiguous. This work aims to research the function and mechanism of SETD2 in HCC based on bioinfo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6b900a51-2378-50dd-9f5d-d3e3df0d3988
DOI: 10.21203/rs.3.rs-3521309/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deficiency of histone H3K36 methyltransferase SETD2 inhibits proliferation and migration of hepatocellular carcinoma through ERK pathwayDOI 10.21203/rs.3.rs-3521309/v1Read

[Research progress on the expression and carcinogenic mechanisms of SETD2 in malignant tumors].Semantic proximity Read

Impact of SETD8/KMT5A Overexpression on Hepatocellular Carcinoma Progression and PrognosisSemantic proximity Read

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Semantic proximity Read

SETD2 as a regulator of N6-methyladenosine RNA methylation and modifiers in cancer.Semantic proximity Read

Loss of Function SETD2 Mutations in Poorly Differentiated Metastases from Two Hürthle Cell Carcinomas of the ThyroidSemantic proximity Read

Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma.Semantic proximity Read

SETD2: an epigenetic modifier with tumor suppressor functionality.Semantic proximity Read

The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.Semantic proximity Read

SETD2 loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a TGF ‐β‐independent mannerSemantic proximity Read

Loss of SETD2, but not H3K36me3, correlates with aggressive clinicopathological features of clear cell renal cell carcinoma patients.Semantic proximity Read

MKL1 Regulates Hepatocellular Carcinoma Cell Proliferation, Migration and Apoptosis via the COMPASS Complex and NF-Κb SignalingSemantic proximity Read

Expression Profile, Prognostic Value, and Therapeutic Potential of NSD2 in Pan-Cancer: A Systematic Analysis Integrating Multi-Omics DataSemantic proximity Read