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Article

Deciphering GB1's Single Mutational Landscape: Insights from MuMi Analysis.

The journal of physical chemistry. B - 22 Aug 2024

Guclu Tandac F, Atilgan Ali Rana, Atilgan Canan

Abstract excerpt

Mutational changes that affect the binding of the C2 fragment of Streptococcal protein G (GB1) to the Fc domain of human IgG (IgG-Fc) have been extensively studied using deep mutational scanning (DMS), and the binding affinity of all single mutations has been measured experimentally in the literature. To investigate the underlying molecular basis, we perform in silico mutational scanning for all possible single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39115184
DOI: 10.1021/acs.jpcb.4c04916
PMCID: PMC11671028

Genes

C2

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