Article
Biophysical Inference of Epistasis and the Effects of Mutations on Protein Stability and Function.
Molecular biology and evolution - 1 Oct 2018
Otwinowski Jakub
Abstract excerpt
Understanding the relationship between protein sequence, function, and stability is a fundamental problem in biology. The essential function of many proteins that fold into a specific structure is their ability to bind to a ligand, which can be assayed for thousands of mutated variants. However, binding assays do not distinguish whether mutations affect the stability of the binding interface or the overall fold....
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