Article

Mapping the Transcriptional Landscape of Drug Responses in Primary Human Cells Using High-Throughput DRUG-seq

2025-06-07

Abstract excerpt

To advance our understanding of drug action in physiologically-relevant systems, we developed a high-throughput transcriptomic atlas of compound responses in primary human cell types. Leveraging the scalable and cost-effective Digital RNA with the pertUrbation of Genes (DRUG-seq) assay, we profiled gene expression responses to 89 pharmacologically-active compounds across six concentrations in four distinct primary...

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Literature Corpus work: 536ee7f8-a64d-59d8-bdf2-1e41635f351e
DOI: 10.1101/2025.06.03.657593

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