Article

Characterizing RNA targets of TDP-43

2015-01-01

Abstract excerpt

TAR-DNA-binding 43kDa protein (TDP-43), is an RNA binding protein that has been linked to the pathology of neurodegenerative diseases such as ALS and FTLD. However, pathological mechanisms involving TDP-43, remain elusive. Current hypotheses have converged on altered RNA processing, due to a loss of function of TDP-43. To gain better insight into the pathogenic mechanisms linked to TDP-43, we hypothesised that a l...

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Literature Corpus work: 6b4988d9-14ed-5b5b-a5a6-a34fbef09f29
DOI: 10.21954/ou.ro.0000eff0

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