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Article

Apocrine carcinoma of the breast: distinctive metabolic reprogramming and high-frequency PIK3CA mutations revealed by molecular and immunohistochemical analysis.

Histopathology - 1 Mar 2026

Nakamura Harumi, Kukita Yoji, Kittaka Nobuyoshi, Kusama Hiroki, Nakayama Takahiro, Tamaki Yasuhiro, Yoshida Ken-Ichi, Kunimasa Kei, Imamura Fumio, Yagi Toshinari

Abstract excerpt

AIMS: Apocrine carcinoma (AC) is a rare and distinct subtype of invasive breast carcinoma, typically characterized by androgen receptor (AR) positivity and negative expression of oestrogen and progesterone receptors. This study aimed to clarify the metabolic and molecular characteristics of AC, with a particular focus on protein expression related to lipid metabolism and the frequency and nature of PIK3CA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41263779
DOI: 10.1111/his.70024

Genes

PIK3CA
ACSL1
ACOX1
AMACR
AR
FASN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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