Article

Tyrosine phosphorylation is critical for ACLY activity in lipid metabolism and cancer

2020-01-20

Abstract excerpt

A fundamental requirement for growth of rapidly proliferating cells is metabolic adaptation to promote synthesis of biomass 1 . ATP citrate lyase (ACLY) is a critical enzyme responsible for synthesis of cytosolic acetyl-CoA, the key building component for de novo fatty acid synthesis and links vital pathways such as carbohydrate and lipid metabolism 2 . The mechanisms of ACLY regulation are not completely under...

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Literature Corpus work: 06f4ef96-216f-5831-aa5e-13027514d071
DOI: 10.1101/2020.01.20.910752

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