Article
Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder.
Psychological medicine - 1 Nov 2014
Sipahi L, Wildman D E, Aiello A E, Koenen K C, Galea S, Abbas A, Uddin M
Abstract excerpt
BACKGROUND: Epigenetic differences exist between trauma-exposed individuals with and without post-traumatic stress disorder (PTSD). It is unclear whether these epigenetic differences pre-exist, or arise following, trauma and PTSD onset. METHOD: In pre- and post-trauma samples from a subset of Detroit Neighborhood Health Study participants, DNA methylation (DNAm) was measured at DNA methyltransferase 1 (DNMT1),...
Topics
- Adult
- Aged
- DNA (Cytosine-5-)-Methyltransferase 1
- DNA (Cytosine-5-)-Methyltransferases
- DNA Methylation
- DNA Methyltransferase 3A
- Epigenesis, Genetic
- Female
- Genetic Predisposition to Disease
- Humans