Article
An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.
Clinical epigenetics - 14 Mar 2020
Logue Mark W, Miller Mark W, Wolf Erika J, Huber Bertrand Russ, Morrison Filomene G, Zhou Zhenwei, Zheng Yuanchao, Smith Alicia K, Daskalakis Nikolaos P, Ratanatharathorn Andrew, Uddin Monica, Nievergelt Caroline M, Ashley-Koch Allison E, Baker Dewleen G, Beckham Jean C, Garrett Melanie E, Boks Marco P, Geuze Elbert, Grant Gerald A, Hauser Michael A, Kessler Ronald C, Kimbrel Nathan A, Maihofer Adam X, Marx Christine E, Qin Xue-Jun, Risbrough Victoria B, Rutten Bart P F, Stein Murray B, Ursano Robert J, Vermetten Eric, Vinkers Christiaan H, Ware Erin B, Stone Annjanette, Schichman Steven A, McGlinchey Regina E, Milberg William P, Hayes Jasmeet P, Verfaellie Mieke
Abstract excerpt
BACKGROUND: Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD). METHODS: In this study, we performed an EWAS of PTSD in a cohort of Veterans (n = 378 lifetime PTSD cases and 135 controls) from the Translational Research Center for TBI and Stress Disorders (TRACTS) cohort assessed using...
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