Article
Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder.
Clinical epigenetics - 13 Jan 2020
Snijders Clara, Maihofer Adam X, Ratanatharathorn Andrew, Baker Dewleen G, Boks Marco P, Geuze Elbert, Jain Sonia, Kessler Ronald C, Pishva Ehsan, Risbrough Victoria B, Stein Murray B, Ursano Robert J, Vermetten Eric, Vinkers Christiaan H, Smith Alicia K, Uddin Monica, Rutten Bart P F, Nievergelt Caroline M
Abstract excerpt
BACKGROUND: Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to and following combat exposure in three cohorts of male military members were analyzed to assess whether DNA methylation profiles are associated with the development of PTSD. A total of 123 PTSD...
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