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Article

Causal evidence linking injury-associated DNA methylation to the risk of developing depression or post-traumatic stress disorder.

Medicine - 17 Apr 2026

Liu Lian, Zhu Ziyu, Du Mengran, Liu Xin, Tan Qiuhao, Xiao Longwei, Zheng Xiaoyang, Huang Zhijian, Liao Zhengbu

Abstract excerpt

Depression and post-traumatic stress disorder (PTSD) are common psychiatric disorders following physical trauma. However, genetic evidence between these disorders is lacking. DNA methylation (DNAm) is implicated in the response to traumatic events and has been proposed as a promising therapeutic target. This study aimed to investigate the causal evidence of injury-associated DNAm and the subsequent onset of...

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Source

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Identifiers

PMID: 41995537
DOI: 10.1097/MD.0000000000048310
PMCID: PMC13095310

Genes

DLGAP2
ERICH1
PCDHA2
PTPRN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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