Article

Disease-guided functional gene mapping across species reveals translational correspondences beyond sequence orthology

2026-05-13

Abstract excerpt

Selecting the correct mouse gene to model a human disease phenotype is critical for translational research, yet sequence-based orthology fails when genes have been lost, duplicated, or functionally rewired between species. Here we present BRIDGE (Biological Rank Integration for Disease Gene Equivalence), a framework that identifies functional mouse equivalents of human disease genes without sequence input. BRIDGE...

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Literature Corpus work: 6aeb0d83-6ac2-5371-9612-7593edde8915
DOI: 10.64898/2026.05.10.720506

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