Article

geneSync: Gene Symbol Harmonization for Large-scale RNA-seq Data Integration

2026-05-07

Abstract excerpt

Cross-cohort integration of transcriptomic data is a routine strategy for boosting statistical power and enhancing generalizability. However, gene nomenclature inconsistencies across datasets—arising from annotation version updates, historical renaming, and synonym reassignment—introduce silent mismatches during feature alignment, causing genes to be falsely classified as absent or split into duplicate features. H...

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Literature Corpus work: ada1a33c-e8bd-5033-aa8f-9c1c4554cc22
DOI: 10.64898/2026.05.04.722831

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