Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1.

FEBS letters - 1 May 2023

Oftedal Bergithe E, Delaleu Nicolas, Dolan David, Meager Anthony, Husebye Eystein S, Wolff Anette S B

Abstract excerpt

Autoimmune polyendocrine syndrome type I (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene and characterised clinically by multiple autoimmune manifestations and serologically by autoantibodies against tissue proteins and cytokines. We here hypothesised that lack of AIRE expression in thymus affects blood immune cells and performed whole-blood microarray analysis (N = 16 APS-I patients vs 16...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Cytokines
Share to Interferon Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polyendocrinopathies, Autoimmune

Source

Identifiers

PMID: 37052889
DOI: 10.1002/1873-3468.14625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1.PMID 37052889Read ↗

Dysfunctional B cell and interferon signaling in autoimmune polyendocrine syndrome type 1Semantic proximity Read ↗

Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1.Semantic proximity Read ↗

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosusSemantic proximity Read ↗

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosusSemantic proximity Read ↗

Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1Semantic proximity Read ↗

Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genesSemantic proximity Read ↗

Long-term follow-up of autoimmune polyendocrine syndrome type 1 in Norway.Semantic proximity Read ↗

Expression signatures with specificity for type I and II IFN response and relevance for autoimmune diseases and cancerSemantic proximity Read ↗

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasSemantic proximity Read ↗

Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature.Semantic proximity Read ↗

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasSemantic proximity Read ↗

Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut HomingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.