Back to search

Article

A human sensory neuron model for varicella-zoster virus latency and reactivation <i>in vitro</i>

2025-12-12

Abstract excerpt

Varicella-zoster virus (VZV) is a ubiquitous human neurotropic alphaherpesvirus that establishes lifelong latency in sensory ganglionic neurons. Subsequent viral reactivation causes herpes zoster, a morbid disease often complicated by neuropathic pain. Mechanisms underlying VZV latency and reactivation are not understood, mostly due to the lack of permissive animal models and challenges of current in vitro latenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
209a2c89-10b7-5bb1-8ac8-68415478e39b
DOI
10.64898/2025.12.12.693952
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A human sensory neuron model for varicella-zoster virus latency and reactivation <i>in vitro</i>DOI 10.64898/2025.12.12.693952
In vitro system using human neurons demonstrates that varicella-zoster vaccine virus is impaired for reactivation, but not latencySemantic proximity
Varicella-zoster virus infection of human dorsal root ganglia <i>in vivo</i>Semantic proximity
An In Vitro Model of Latency and Reactivation of Varicella Zoster Virus in Human Stem Cell-Derived NeuronsSemantic proximity
An Immortalized Human Dorsal Root Ganglion Cell Line Provides a Novel Context To Study Herpes Simplex Virus 1 Latency and ReactivationSemantic proximity
Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived NeuronsSemantic proximity
Differentiated Neuroblastoma Cells Provide a Highly Efficient Model for Studies of Productive Varicella-Zoster Virus Infection of Neuronal CellsSemantic proximity
Neuronal Subtype and Satellite Cell Tropism Are Determinants of Varicella-Zoster Virus Virulence in Human Dorsal Root Ganglia Xenografts In VivoSemantic proximity
Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of LatencySemantic proximity
Varicella Zoster Virus in the Nervous SystemSemantic proximity
Modulation of Voltage-Gated Sodium Channel (VGSC) Activity in Human Dorsal Root Ganglion (DRG) Neurons by Herpesvirus Quiescent InfectionSemantic proximity
Human Sensory Neurons Derived from Induced Pluripotent Stem Cells Support Varicella-Zoster Virus InfectionSemantic proximity
A human stem cell-derived neurosensory-epithelial circuitry on-a-chip to model herpes simplex virus reactivationSemantic proximity
Select a neighboring publication to make it the new centre.