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Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived Neurons

8 Jun 2017

Abstract excerpt

Herpes simplex virus 1 (HSV-1) uses latency in peripheral ganglia to persist in its human host, however, recurrent reactivation from this reservoir can cause debilitating and potentially life-threatening disease. Most studies of latency use live-animal infection models, but these are complex, multilayered systems and can be difficult to manipulate. Infection of cultured primary neurons provides a powerful...

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PMID: 28594343
DOI: 10.3390/pathogens6020024

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