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Article

Long-term effects of recurrent intermittent hypoxia and hyperoxia on respiratory system mechanics in neonatal mice.

Pediatric research - 1 Apr 2017

Dylag Andrew M, Mayer Catherine A, Raffay Thomas M, Martin Richard J, Jafri Anjum, MacFarlane Peter M

Abstract excerpt

BACKGROUND: Premature infants are at increased risk for wheezing disorders. Clinically, these neonates experience recurrent episodes of apnea and desaturation often treated by increasing the fraction of inspired oxygen (FIO2). We developed a novel paradigm of neonatal intermittent hypoxia with subsequent hyperoxia overshoots (CIHO/E) and hypothesized that CIHO/E elicits long-term changes on pulmonary mechanics in...

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Identifiers

PMID: 27842056
DOI: 10.1038/pr.2016.240
PMCID: PMC5395323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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