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Article

Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle.

American journal of human genetics - 11 Jul 2013

Guo Yu, Wei Xiaomu, Das Jishnu, Grimson Andrew, Lipkin Steven M, Clark Andrew G, Yu Haiyuan

Abstract excerpt

To better understand different molecular mechanisms by which mutations lead to various human diseases, we classified 82,833 disease-associated mutations according to their inheritance modes (recessive versus dominant) and molecular types (in-frame [missense point mutations and in-frame indels] ve...

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Share to Antigens, Differentiation
Share to Genetic Diseases, Inborn
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23791107
DOI: 10.1016/j.ajhg.2013.05.022
PMCID: PMC3710751

Genes

MID2
TRIM42
TRIM27

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23791107-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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