Article

Epigenomic embedding of childhood adversity links to disease risk and chronic immune changes

2025-12-05

Abstract excerpt

Childhood adversity (CA) is a major risk factor for diverse psychiatric and physical disorders and is thought to interact with genetic variation to influence disease vulnerability via gene-environment interplay (G×E). DNA methylation (DNAm) may mediate these effects, particularly within the immune system, which is implicated in the long-term health consequences of CA. We mapped the epigenetic embedding of CA in im...

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Literature Corpus work: 6ab92942-33de-5270-a633-65550872fb7d
DOI: 10.64898/2025.12.04.25341605

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