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DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study

15 May 2024

Abstract excerpt

Childhood adversity is an important risk factor for adverse health across the life course. Epigenetic modifications, such as DNA methylation (DNAm), are a hypothesized mechanism linking adversity to disease susceptibility. Yet, few studies have determined whether adversity-related DNAm alterations are causally related to future health outcomes or if their developmental timing plays a role in these relationships....

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PMID: 38754872
DOI: 10.1093/aje/kwae072

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