Article
Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2014
Nickerson Michael L, Dancik Garrett M, Im Kate M, Edwards Michael G, Turan Sevilay, Brown Joseph, Ruiz-Rodriguez Christina, Owens Charles, Costello James C, Guo Guangwu, Tsang Shirley X, Li Yingrui, Zhou Quan, Cai Zhiming, Moore Lee E, Lucia M Scott, Dean Michael, Theodorescu Dan
Abstract excerpt
PURPOSE: Genetic analysis of bladder cancer has revealed a number of frequently altered genes, including frequent alterations of the telomerase (TERT) gene promoter, although few altered genes have been functionally evaluated. Our objective is to characterize alterations observed by exome sequencing and sequencing of the TERT promoter, and to examine the functional relevance of histone lysine (K)-specific...
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