Article

ZRANB1 promotes cell proliferation and lymph node metastasis through SF3B3-mediated alternative splicing of CHEK2 in urothelial bladder cancer

2026-02-25

Abstract excerpt

<title>Abstract</title> <p>Urothelial bladder cancer (UBC) poses a considerable threat to public health, and its clinical management is challenged by high recurrence rates and tendency to progression. While dysregulation of the ubiquitin-proteasome system (UPS) is a hallmark of tumourigenesis, the specific landscape of deubiquitinating enzymes (DUBs) in UBC remains largely underexplored. Multiple transcriptomic d...

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Literature Corpus work: 0df975c8-622c-5900-8253-e4eb7d1c55d8
DOI: 10.21203/rs.3.rs-8816203/v1

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