Article

Kasugamycin is a novel chitinase 1 inhibitor with strong antifibrotic effects on pulmonary fibrosis

2021-02-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Pulmonary fibrosis is a devastating lung disease with few therapeutic options. Chitinase 1 (CHIT1), an 18 glycosyl hydrolase family member, contributes to the pathogenesis of pulmonary fibrosis through regulation of Transforming Growth Factor (TGF)-β signaling and effector function. Therefore, CHIT1 is a potential therapeutic target of pulmonary fibrosis. <h4>Objectives</h4>...

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Literature Corpus work: 10567ff4-01b5-51e2-9893-0571d98442e8
DOI: 10.1101/2021.02.25.432796

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