Mechanoresilience of lysosomes conferred by TMEM63A

Abstract excerpt

Lysosomes are subject to perturbations that can cause damage to their limiting membrane. Osmotic shifts, pore-forming toxins, and the growth of luminal polymers or pathogens all stand to increase lysosomal membrane tension and/or disrupt the bilayer. In some contexts, this leads to lysosomal rupture and cell death. Here we describe a mechanism that enables lysosomes to sense and respond to acute increases in tensi...

Topics

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• Cryoelectron Microscopy
• HEK293 Cells
• Ion Channels
• Mechanotransduction, Cellular
• Membrane Proteins
• Models, Molecular
• Mutation
• Protein Multimerization

Identifiers and source

Literature Corpus work

6a7d18fb-32fe-5fe3-a610-8b5d27fcdb6a

DOI

10.64898/2025.12.18.695245