Article

Evaluation of PRKACA as a Therapeutic Target for Fibrolamellar Carcinoma

2022-01-31

Abstract excerpt

<h4>Background & Aims</h4> Fibrolamellar carcinoma (FLC) is a rare, difficult-to-treat liver cancer primarily affecting pediatric and adolescent patients, and for which precision medicine approaches have historically not been possible. The DNAJB1-PRKACA gene fusion was identified as a driver of FLC pathogenesis. We aimed to assess whether FLC tumors maintain dependency on this gene fusion and determine if PRKACA...

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Literature Corpus work: dc4a8b76-bddf-5bb8-8767-aac4634af287
DOI: 10.1101/2022.01.31.477690

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