Detecting significant features in modeling microRNA-target interactions

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. Up to 60% of human genes are putative targets of one or more miRNAs. Several prediction tools are available to suggest putative miRNA targets, h...

Topics

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• Artificial Intelligence
• Gene Expression
• MicroRNAs
• Mutation
• Oligonucleotide Array Sequence Analysis
• Polymorphism, Single Nucleotide
• Real-Time Polymerase Chain Reaction
• Support Vector Machine

Identifiers and source

Literature Corpus work

6a67511e-7239-571c-8209-31f68695ac49

DOI

10.7287/peerj.preprints.3337v1