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<i>In vivo</i> CRISPRi screen reveals the differential requirement for mitochondrial respiratory chain function between <i>in vivo</i> and <i>in vitro</i> tumor growth

2021-10-03

Abstract excerpt

<h4>ABSTRACT</h4> The Warburg effect, aerobic glycolysis, is a hallmark feature of cancer cells grown in culture. However, the relative roles of glycolysis and respiratory metabolism in supporting in vivo tumor growth and significant processes such as tumor dissemination and metastases remain poorly understood, particularly on a systems level. Using a CRISPRi mini-library enriched for mitochondrial ribosomal pro...

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Literature Corpus work
6a65c8ba-8ec3-52c5-beb9-28f1d25b3031
DOI
10.1101/2021.10.03.462937
Open publication

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