Article

NPEPPS is a novel and druggable driver of platinum resistance

2021-03-04

Abstract excerpt

<h4>ABSTRACT</h4> There is an unmet need to improve efficacy of platinum-based cancer chemotherapy. Using multi-omic assessment of cisplatin-responsive and -resistant human bladder cancer cell lines and whole-genome CRISPR screens, we identified Puromycin-Sensitive Aminopeptidase, NPEPPS, as a novel driver of cisplatin resistance. NPEPPS depletion sensitizes resistant bladder cancer cells to cisplatin in vitro a...

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Literature Corpus work: 7f874c4d-588e-567b-9019-25883babfd12
DOI: 10.1101/2021.03.04.433676

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