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Memory deficits in hypertensive ApoE4 mice reversed by P2Y12 inhibition via different mechanisms in males and perimenopausal females

2025-09-26

Abstract excerpt

<title>Abstract</title> <p>Apolipoprotein E4 (ApoE4) genotype, hypertension, and biological sex are critical risk factors for Alzheimer’s disease and related dementias. Yet, their combined impact on early cerebrovascular dysfunction, brain inflammation, and memory impairment remains poorly understood. We developed a translational mouse model incorporating human ApoE4, hypertension via angiotensin II infusion, and...

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Literature Corpus work
6a1821b7-bff7-5ca8-867f-441d3c9d7ca2
DOI
10.21203/rs.3.rs-7643285/v1
Open publication

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Memory deficits in hypertensive ApoE4 mice reversed by P2Y12 inhibition via different mechanisms in males and perimenopausal femalesDOI 10.21203/rs.3.rs-7643285/v1
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