The interplay between dormant mutated cells and tumor promotion by chronic tissue damage in determining cancer risk

Abstract excerpt

While the causal role of mutagenic carcinogens in tumor development is well established, the relative contribution of environmental tumor promoting factors, wounding, and chronic inflammation is still unclear. Recent sequencing studies have suggested that most environmental carcinogens act as promoters rather than through mechanisms that involve direct induction of point mutations, but whether cancer risk factors...

Topics

Open a Topic to create a Post that cites this publication.

• Carcinogens
• Disease Models, Animal
• Mice
• Mutation
• Neoplasms
• Skin
• Skin Neoplasms
• Tetradecanoylphorbol Acetate

Identifiers and source

Literature Corpus work

6a15fc77-74d4-5f38-a0a3-8fb1bc03f2c6

DOI

10.1101/2024.01.24.577147