Article

Copper metabolism in metallothionein-null mice fed a high-zinc diet

1998-10-01

Abstract excerpt

Humans and animals develop low copper (Cu) status when fed diets containing large amounts of zinc (Zn) for an extended period. Current theory states that Zn-induced metallothionein (MT) in the intestinal mucosa binds Cu and prevents its absorption. We tested this theory by using a mouse model with a disruption in the MT gene that renders it incapable of producing functional MT-I and MT-II (MT-null). If the theory...

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Literature Corpus work: 69fe2c66-82cc-5589-9897-707bf087a100
DOI: 10.1016/s0955-2863(98)00055-2

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