Regional brain distribution of metallothionein, zinc and copper in toxic milk mutant and transgenic mice.

Abstract excerpt

The regional distribution of metallothionein (MT), zinc and copper was measured in brains of transgenic MT-I overexpressor (MT-I*) mice, MT-I/MT-II gene knockout (MT-I/MT-II null) mice, and in brains of control C57BL/6J mice with normal MT expression. Toxic milk (tx) mutant mice with abnormally high MT and copper accumulation were also assessed. Although there were significant differences in MT levels (assessed...

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