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Article

Metallothionein is crucial for safe intracellular copper storage and cell survival at normal and supra-physiological exposure levels.

The Biochemical journal - 1 Mar 2004

Tapia Lucía, González-Agüero Mauricio, Cisternas Mónica F, Suazo Miriam, Cambiazo Verónica, Uauy Ricardo, González Mauricio

Abstract excerpt

MTs (metallothioneins) increase the resistance of cells to exposure to high Cu (copper) levels. Characterization of the MT-Cu complex suggests that MT has an important role in the cellular storage and/or delivery of Cu ions to cuproenzymes. In this work we investigate how these properties contribute to Cu homoeostasis by evaluating the uptake, accumulation and efflux of Cu in wild-type and MT I/II null rat...

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Identifiers

PMID: 14627437
DOI: 10.1042/BJ20031174
PMCID: PMC1223976

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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