Article

LC-mHTT-AN2 oversees lactate transport, hypoxia, and glucose homeostasis through dual regulation of MCT-1/4 in the tumor microenvironment

2024-02-27

Abstract excerpt

<h4>Background: </h4> Cancer cells have accelerated glycolysis rate, resulting in excessive lactate generation, which is critical in rapidly growing cancerous cells. Lactate is primarily transported by MCT-1/MCT-4, the two H+/lactate transporters that promote cellular proliferation and growth. Through in-silico, in-vitro , and in-vivo investigation, we aimed to find new dual MCT-1 and MCT-4 inhibitor for therapeut...

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Literature Corpus work: 42f07b13-e074-516c-9216-84e9fc647500
DOI: 10.21203/rs.3.rs-3981481/v1

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