Article

Genomic Dimensionality Bounds Mixed-Model Association Power, Fine-Mapping Resolution, and Genomic Prediction Reliability

2026-06-05

Abstract excerpt

Mixed-model genome-wide association studies (GWAS) behave differently in livestock than in humans, yet a unified explanation is lacking. Analyses using the full genomic relationship matrix (full-GRM; from genome-wide SNPs) yield only a few significant peaks even with hundreds of thousands of animals, whereas leave-one-chromosome-out (LOCO), numerator-relationship-matrix, and sparse-GRM approaches report many broad...

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Literature Corpus work: 69f5052a-fcc0-59fd-8b38-ab0d8a4d12b5
DOI: 10.64898/2026.06.02.729628

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