Article
Comparison of gene-based rare variant association mapping methods for quantitative traits in a bovine population with complex familial relationships.
Genetics, selection, evolution : GSE - 17 Aug 2016
Zhang Qianqian, Guldbrandtsen Bernt, Calus Mario P L, Lund Mogens Sandø, Sahana Goutam
Abstract excerpt
BACKGROUND: There is growing interest in the role of rare variants in the variation of complex traits due to increasing evidence that rare variants are associated with quantitative traits. However, association methods that are commonly used for mapping common variants are not effective to map rare variants. Besides, livestock populations have large half-sib families and the occurrence of rare variants may be...
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