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Article

OmiGA for ultra-efficient molecular quantitative trait loci mapping.

Nature communications - 12 Feb 2026

Teng Jinyan, Zhang Wenjing, Gong Wentao, Chen Jiajian, Gao Yahui, Fang Lingzhao, Zhang Zhe

Abstract excerpt

Molecular quantitative trait loci (molQTL) mapping is one of the most popular approaches to systematically characterize functional impacts of genomic variants, leading to advanced understanding of the regulatory mechanisms underpinning complex traits and diseases. However, when applied to high-throughput molecular phenotypes, the existing molQTL mapping tools often implement simple linear models, overlooking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41680153
DOI: 10.1038/s41467-026-68978-0
PMCID: PMC13009172

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