Article

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

2023-05-09

Abstract excerpt

Dopa-responsive dystonia (DRD) and Parkinson’s disease (PD) are movement disorders caused by the dysfunction of nigrostriatal dopaminergic neurons. Identifying druggable pathways and biomarkers for guiding therapies is crucial due to the debilitating nature of these disorders. Recent genetic studies have identified variants of GTP cyclohydrolase-1 (GCH1), the rate-limiting enzyme in tetrahydrobiopterin (BH4) synth...

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Literature Corpus work: 444b9096-fafb-5e0e-a97a-61b68aec70c0
DOI: 10.1101/2023.05.08.539795

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