Article

Silencing Of The DNA Damage Repair Regulator PPP1R15A Sensitizes Acute Myeloid Leukemia Cells To Chemotherapy

2024-01-31

Abstract excerpt

<title>Abstract</title> <p>Acute Myeloid Leukemia (AML) is a life-threatening disease whose induction treatment consists of combination chemotherapy with Idarubicin and Cytarabine for fit patients. Treatment failures are frequent, urging the need for novel treatments for this disease. The DNA Damage Response Mechanism (DDR) comprises numerous molecules and pathways intended to arrest the cell cycle until DNA dama...

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Literature Corpus work: 69ccfdc1-cf5b-5f7a-a9ac-88c62ac21422
DOI: 10.21203/rs.3.rs-3891837/v1

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